منابع مشابه
Transition states in protein folding
The folding dynamics of small single-domain proteins is a current focus of simulations and experiments. Many of these proteins are ‘two-state folders’, i.e. proteins that fold rather directly from the denatured state to the native state, without populating metastable intermediate states. A central question is how to characterize the instable, partially folded conformations of two-state proteins...
متن کاملIs protein folding hierarchic? II. Folding intermediates and transition states.
The folding reactions of some small proteins show clear evidence of a hierarchic process, whereas others, lacking detectable intermediates, do not. Evidence from folding intermediates and transition states suggests that folding begins locally, and that the formation of native secondary structure precedes the formation of tertiary interactions, not the reverse. Some notable examples in the liter...
متن کاملProtein Folding as a Quantum Transition Between Conformational States
The importance of torsion vibration in the transmission of life information is indicated. The localization of quantum torsion state is proved. Following these analyses a formalism on the quantum theory of conformation-electron system is proposed. The conformational-electronic transition is calculated by non-adiabatic operator method. The protein folding is viewed from conformational quantum tra...
متن کاملUnspecific hydrophobic stabilization of folding transition states.
Here we present a method for determining the inference of non-native conformations in the folding of a small domain, alpha-spectrin Src homology 3 domain. This method relies on the preservation of all native interactions after Tyr/Phe exchanges in solvent-exposed, contact-free positions. Minor changes in solvent exposure and free energy of the denatured ensemble are in agreement with the revers...
متن کاملThe origins of asymmetry in the folding transition states of protein L and protein G.
Topology has been shown to be an important determinant of many features of protein folding; however, the delineation of sequence effects on folding remains obscure. Furthermore, differentiation between the two influences proves difficult due to their intimate relationship. To investigate the effect of sequence in the absence of significant topological differences, we examined the folding mechan...
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ژورنال
عنوان ژورنال: Communications in Computational Physics
سال: 2010
ISSN: 1815-2406,1991-7120
DOI: 10.4208/cicp.2009.08.202